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The first CorEuStem (European COST action surrounding stem cells) short term scientific mission allowed hands-on training on hPSC culture, primary cells transduction towards pluripotency and small molecule screening using hPSCs. Karina Goluba, research assistant from University of Latvia, Riga (Latvia) was introduced to the Medical Cell Biology lab run by Professor Jolanda van Hengel, where she learned how to reprogram somatic cells into iPSCs, basic procedures regarding hPSCs maintenance and differentiation. ![]() “Overall, during this mission I learned all the planned methods and fully implemented the goals set at the beginning. I have gained very good experience in working with pluripotent stem cells…and now I can feel confident working with them soon in my PhD work and in other projects. This STMS also helped establish scientific connection between our host institutions.” Good news! Our paper named Microscopic visualization of Cell-Cell Adhesion Complexes at Micro and Nanoscale was published in Fronties in Cell and Developmental Biology, April 20th 2022. In this review, we discuss the main light and electron microscopy techniques used to unravel the structure and composition of the three cell-cell contacts in epithelial and endothelial cells. It functions as a guide to pick the appropriate imaging technique(s) for the adhesion complexes of interest. We also point out the latest techniques that have emerged. At the end, we discuss the problems investigators encounter during their cell-cell adhesion research using microscopic techniques.
Read the paper by clicking this link. |