![]() Our lab succesfully generated an iPSC line from a patient suffering from Marfan syndrome (carrying a heterozygous c.7754T>C variant in FBN1). Additionally, an isogenic control was generated using CRISPR/Cas9 technology. These iPSCs can be readily differentiated into cell types of interest, such as vascular smooth muscle cells, and cardiomyocytes. This isogenic pair will help advance fundamental knowledge concerning Marfan Syndrome. You can access the paper using this link.
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